{"id":1435,"date":"2018-04-04T14:59:24","date_gmt":"2018-04-04T12:59:24","guid":{"rendered":"http:\/\/www.newslab.sk\/2018\/04\/04\/monitoring-ebv-infekcie-u-detskych-pacientov-po-transplantacii-krvotvornych-buniek-tkb\/"},"modified":"2018-04-04T15:07:42","modified_gmt":"2018-04-04T13:07:42","slug":"monitoring-ebv-infekcie-u-detskych-pacientov-po-transplantacii-krvotvornych-buniek-tkb","status":"publish","type":"post","link":"https:\/\/www.newslab.sk\/en\/monitoring-ebv-infekcie-u-detskych-pacientov-po-transplantacii-krvotvornych-buniek-tkb\/","title":{"rendered":"Monitoring EBV infection in children patients after Hematopoietic Stem Cell Transplantation (HSCT)"},"content":{"rendered":"<pre><strong><span style=\"color: #ff0000;\">*All tables, charts, graphs and pictures that are featured in this article can be found in the .pdf attachment at the end of the paper.<\/span> <\/strong><\/pre>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>*All tables, charts, graphs and pictures that are featured in this article can be found in the .pdf attachment at the end of the paper. &nbsp;<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"footnotes":""},"categories":[292],"tags":[648,883,882,880],"class_list":["post-1435","post","type-post","status-publish","format-standard","hentry","category-microbiology","tag-epstein-barr-virus","tag-hematopoietic-stem-cell-transplantation-hsct","tag-post-transplant-lymphoproliferative-disease-ptld","tag-rituximab-en","typ_clanku-original-work"],"acf":{"abstrakt":"<p>Epstein-Barr Virus (EBV) is a ubiquitous Y-herpesvirus. EBV usually established a lifelong asymptomatic infec\u00adtion in immunocompetent people. On the other hand, EBV can cause severe problems in immunocompromised patients. In recipients of allogeneic hematopoietic stem cell transplant (allo-HSCT), EBV infection may progress to the onset of a post-transplant lymphoproliferative disease (PTLD). EBV-PTLD is a life-threatening complication with a high mortality rate of 80-90 % and incidence between 0.5 &#8211; 1.3 %. In 71 paediatric allogeneic allo-HSCT re\u00adcipients transplanted at Department of Paediatric Haematology and Oncology, Haematopoietic Stem Cell Trans\u00adplantation Unit, Comenius University Children&#8217;s Hospital, Bratislava between 2013 and 2017, there were inves\u00adtigated the impact of routine EBV DNA monitoring the incidence of EBV infection, the potential risk factors and the development of EBV-PTLD. Quantitative realtime PCR assay was performed on all blood samples for all pa\u00adtients. High EBV DNAemia levels were observed in 57 % of the actively infected recipients (52 %). Matched-un\u00adrelated donor transplant and CMV reactivation were associated with the high viral load. Two patients developed EBV PTLD. The key to the initiation of early treatment is regular EBV DNA PCR monitoring in correlation with clin\u00adical symptoms and presence of risk factors. Immunotherapeutic intervention includes reduction of immunosup\u00adpression and administration of anti-CD20 monoclonal antibody (rituximab), adoptive immunotherapy with the administration of EBV-specific T-cells or donor lymphocyte infusion (DLI).<\/p>\n<p><strong>Keywords:<\/strong> Epstein-Barr Virus, post-transplant lymphoproliferative disease (PTLD), Hematopoietic Stem Cell Transplantation (HSCT), rituximab<\/p>\n","casopis":[{"ID":1361,"post_author":"7","post_date":"2018-04-04 13:46:52","post_date_gmt":"2018-04-04 11:46:52","post_content":"<ul>\r\n \t<li>Mature ovarian teratoma with pneumatosis cystoideslike appearance \u2013 morphological and immunohistochemical study<\/li>\r\n \t<li>Incidental pelvic lymphangioleiomyomatosis in case of uterine carcinoma. Report of the case and search for similar lesions in series of staging lymhadenectomies<\/li>\r\n \t<li>Environmental oestrogen bisphenol A and disorders in woman fertility<\/li>\r\n \t<li>Monitoring EBV infection in children patients after Hematopoietic Stem Cell Transplantation (HSCT)<\/li>\r\n \t<li>The rare care of infection caused by Vibrio cholerae non-O1, non-O139 in clinical practice in Slovakia<\/li>\r\n<\/ul>","post_title":"Newslab","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"newslab-2018_1","to_ping":"","pinged":"","post_modified":"2018-04-04 13:51:52","post_modified_gmt":"2018-04-04 11:51:52","post_content_filtered":"","post_parent":0,"guid":"http:\/\/www.newslab.sk\/?post_type=casopis&#038;p=1361","menu_order":0,"post_type":"casopis","post_mime_type":"","comment_count":"0","filter":"raw"}],"strana":"21","upload_clanok":{"ID":1433,"id":1433,"title":"NEWSLAB 1-2018_Kov\u00e1\u010dov\u00e1","filename":"NEWSLAB-1-2018_Kov\u00e1\u010dov\u00e1.pdf","filesize":304176,"url":"https:\/\/www.newslab.sk\/wp-content\/uploads\/2018\/04\/NEWSLAB-1-2018_Kov\u00e1\u010dov\u00e1.pdf","link":"https:\/\/www.newslab.sk\/en\/monitoring-ebv-infekcie-u-detskych-pacientov-po-transplantacii-krvotvornych-buniek-tkb\/newslab-1-2018_kovacova-2\/","alt":"","author":"7","description":"","caption":"","name":"newslab-1-2018_kovacova-2","status":"inherit","uploaded_to":1435,"date":"2018-04-04 12:09:10","modified":"2018-04-04 12:09:10","menu_order":0,"mime_type":"application\/pdf","type":"application","subtype":"pdf","icon":"https:\/\/www.newslab.sk\/wp-includes\/images\/media\/document.png"}},"_links":{"self":[{"href":"https:\/\/www.newslab.sk\/en\/wp-json\/wp\/v2\/posts\/1435","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newslab.sk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newslab.sk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newslab.sk\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newslab.sk\/en\/wp-json\/wp\/v2\/comments?post=1435"}],"version-history":[{"count":0,"href":"https:\/\/www.newslab.sk\/en\/wp-json\/wp\/v2\/posts\/1435\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.newslab.sk\/en\/wp-json\/wp\/v2\/media?parent=1435"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newslab.sk\/en\/wp-json\/wp\/v2\/categories?post=1435"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newslab.sk\/en\/wp-json\/wp\/v2\/tags?post=1435"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}