Tumour genesis is accompanied by the activation of antitumour immunity, which has the potential to influence the biological behaviour of the tumour. The present study...
Vaccine vulnerabilities: can we prevent them? – SARS-CoV-2 case study
Michaela Hýblová, Patrik Krumpolec, Klaudia Babišová, Gabriel Minárik
The discovery of antibiotics by Alexander Fleming and the introduction of vaccination are undoubtedly among the most remarkable medical milestones in modern human history. In...
Keywords: ADE, COVID-19, mRNA vaccines; COVID 19, mRNA vakcíny, VITT
Whole-genome sequencing methods for CNV detection
Zuzana Klinovská, Marcel Kucharik, Jaroslav Budiš, Tomáš Szemes
The importance of copy number variants (CNVs) in reference to human health is rising continuously. They are linked to various types of disorders, syndromes and...
Extracellular mitochondrial DNA as a non-invasive biomarker of cancer
Silvia Bokorová, Katarína Suroviaková, Ondrej Pös, Werner Krampl, Mgr. Jakub Styk, Tomáš Szemes
Mitochondria play an essential role in the energy metabolism of cells and thus affect essential cellular functions possibly associated with cancer development. Mitochondrial DNA (mtDNA)...
Keywords: biomarker, cf-mtDNA, heteroplasmy, mitochondria
The role of epigenetics in endometrial cancer
Dominik Kodada, Vanda Repiska, Gabriel Minárik, Vanda Repiska
Endometrial adenocarcinoma, often referred as the endometrial cancer, is the most common kind of uterine cancer. It´s incidence is rising in last decades and each...
Metabolomics: a potential tool for an individual approach to depressive diseases
Depresia každoročne prispieva k celosvetovej záťaži chorôb. Počas krízy COVID-19 sa výskyt porúch nálad či dokonca depresie výrazne zvýšil. Napriek pribúdajúcim informáciám presné základné mechanizmy...
Whole Genome Sequencing as a Tool for Characterization of Neonatal Meningitis Escherichia coli
Michal Andrezál, Lukáš Pazderka, Tomáš Szemes, Hana Drahovská
Neonatal meningitis is a life-threatening disease with high mortality rate and possible neurological sequelae with neonatal meningitis E. coli strains (NMEC) being of the primary...
Impaired tissue repair is a concomitant feature of diabetes mellitus (pathophysiological study and case report)
Diabetes mellitus, with its complications, is one of the serious chronic diseases with an increasing prevalence in the population. Common complications of poorly compensated diabetes...
Using immunohistochemistry to examine MMR protein expression in endometrial tumours is a suitable method for the primary selection of potential cases with Lynch syndrome
Kristína Mikuš-Kuracinová, Veronika Mihál, Veronika Poorová, Monika Sekerešová
Lynch syndrome (LS), or hereditary non-polyposis colorectal cancer (HNPCC), is an autosomal dominant disease in which mutations occur in genes for MMR proteins responsible for...